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The JAMA Network > April 1990 , Vol 125, No. 4 < Previous in this Issue | Next in this Issue > PDF ARTICLE Published onlineApril 1990 Interferon Gamma and Tumor Necrosis Factor Alpha:Use in Gram-negative Infection After Shock Mark A. Malangoni, MD; David H. Livingston, MD; Gerald Sonnenfeld, PhD; Hiram C. Polk Jr, MD [ + ] Author Affiliations Arch Surg.1990;125(4):444-446. doi:10.1001/archsurg.1990.01410160030005. [ + ] More ABSTRACT • Shock increases the propensity to develop infection after injury or operation. This study evaluated the effect of cefoxitin, interferon gamma (INF-γ), and tumor necrosis factor alpha (TNF-α) on the development of a polymicrobial soft-tissue infection. After sham operation or hemorrhagic shock and resuscitation, Sprague-Dawley rats were inoculated with 1 × 108Escherichia coliand 1 × 109Bacteroides fragilisin a 5% fecal suspension. Animals received either no treatment, cefoxitin, recombinant rat INF-γ, recombinant human TNF-α, or cefoxitin/cytokine combinations. Cefoxitin reduced abscess size by 57% in animals without shock but only by 26% after shock. Although neither INF-γ nor TNF-α alone had a salutary effect when given with cefoxitin in animals after shock, INF-γ and TNF-α reduced abscess size by 50% and 55%, respectively. These results suggest that INF-γ and TNF-α may be useful to reduce the severity of mixed gram-negative infections after shock with bacterial contamination. (Arch Surg. 1990;125:444-446) Sign In to Access Full Content Username Password Sign In Register Now Learn how to get mobile access Choose content to search Home Online First Current Issue Topics All Issues Multimedia Sign In © American Medical Association. All Rights Reserved.